Title:Stem Cells, a New Generation Model for Predictive Nano Toxicological Assessment
Volume: 16
Issue: 10
Author(s): Remya Nirmal Suma and Parayanthala Valappil Mohanan
Affiliation:
Keywords:
Apoptosis, bio-nano interactions, nano materials stem cells, oxidative stress, predictive nano toxicology.
Abstract: With the recent advancement in nanoscience and nanotechnology, there is a growing demand for assessment
of the toxicological effects of nano materials to humans and other biological systems. And a predictive
toxicology approach that uses in vitro screening assays in conjunction with in vivo study results are widely employed
in nano safety evaluation. In recent years stem cells have gained wide attention in the scientific community
owing to their potential benefits for various applications in health care systems. Stem cells are undifferentiated
cells that have high replicative potential and multilineage differentiation capacity. And therefore, stem cells could
be exploited for developing in vitro model systems to study nanomaterials interaction with the biological systems
and a potential tool to predict toxicity in humans. The details provided in this article will give an overview of optimizing stem cell technology
in predicting the toxicity of nano materials the essential features of the article.
