Title:New Horizons in the Etiopathogenesis and Non-Invasive Diagnosis of Endometriosis.
Volume: 15
Issue: 8
Author(s): A Zubrzycka, M. Zubrzycki, A. Janecka and M. Zubrzycka
Affiliation:
关键词:
子宫内膜异位症发病机制，子宫内膜异位症风险因素，危险因素，妇科疾病，生物标志物的发病机制。
摘要: Endometriosis is one of the most common gynecological inflammatory diseases,
occurring in adolescents and women in the reproductive age group and leading to infertility. The precise
etiopathogenesis of endometriosis is unknown, but several theories concerning the phenomena involved in its
development have been proposed. Beside classic retrograde menstruation, these include lymphatic and
vascular metastases, iatrogenic direct implantation, coelomic metaplasia, embryonic remnants and
mesenchymal cell differentiation or induction; the persistence of a form of embryonic endometriosis may also
be involved, as well as the theory of the possible role of endometrial stem/progenitor cells. This paper deals
with other risk factors which may be potentially involved in the etiopathogenesis of endometriosis, including the
immune, inflammatory, endocrine, genetic, anatomical and environmental factors. At present, endometriosis
can only be diagnosed with surgery, where laparoscopy is considered a gold standard. Therefore, there is an
urgent need for a test allowing to detect non-invasive molecular biomarkers to identify the symptoms of
endometriosis early on in disease development. A thorough understanding of the etiopathogenesis of
endometriosis is essential toward the development of novel diagnostic assays and effective treatments of the
disease.
