Title:Role of microRNAs in Vascular Remodeling
Volume: 15
Issue: 8
Author(s): Y. -C. Fang and C. -H. Yeh
Affiliation:
关键词:
心血管疾病，内皮细胞，巨噬细胞，microRNA，增生，平滑肌细胞。
摘要: Besides being involved in the gradual formation of blood vessels during embryonic
development, vascular remodeling also contributes to the progression of various
cardiovascular diseases, such as; myocardial infarction, heart failure, atherosclerosis,
pulmonary artery hypertension, restenosis, aneurysm, etc. The integrated mechanisms;
proliferation of medial smooth muscle cell, dysregulation of intimal endothelial cell, activation
of adventitial fibroblast, inflammation of macrophage, and the participation of extracellular
matrix proteins are important factors in vascular remodeling. In the recent studies,
microRNAs (miRs) have been shown to be expressed in all of these cell-types and play
important roles in the mechanisms of vascular remodeling. Therefore, some miRs may be
involved in prevention and others in the aggravation of the vascular lesions. miRs are small,
endogenous, conserved, single-stranded, non-coding RNAs; which degrade target RNAs or inhibit translation
post-transcriptionally. In this paper, we reviewed the function and mechanisms of miRs, which are highly
expressed in various cells types, especially endothelial and smooth muscle cells, which are closely involved in
the process of vascular remodeling. We also assess the functions of these miRs in the hope that they may
provide new possibilities of diagnosis and treatment choices for the related diseases.
