Novel Synthetic Compounds as Potential Anticryptococcal Agents

Title:Novel Synthetic Compounds as Potential Anticryptococcal Agents

Volume: 12 Issue: 6

Author(s): Soraya M. Z. M. D. Ferreira, Cleiton M. da Silva, Ângelo de Fátima and Rossimiriam P. Freitas

Affiliation:

Keywords: Antifungal, azole, cryptococcosis, Cryptococcus, heterocycles, natural product derivatives, peptide, phospholipidic compounds.

Abstract: Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review compiles examples of novel synthetic compounds, which could be used as templates for developing novel drugs for the treatment of Cryptococcus infections.

Cite this article as:

Ferreira M. Z. M. D. Soraya, da Silva M. Cleiton, Fátima de Ângelo and Freitas P. Rossimiriam, Novel Synthetic Compounds as Potential Anticryptococcal Agents, Current Organic Synthesis 2015; 12(6) . https://dx.doi.org/10.2174/157017941206150828111041