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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Novel Synthetic Compounds as Potential Anticryptococcal Agents

Author(s): Soraya M. Z. M. D. Ferreira, Cleiton M. da Silva, Ângelo de Fátima and Rossimiriam P. Freitas

Volume 12, Issue 6, 2015

Page: [730 - 745] Pages: 16

DOI: 10.2174/157017941206150828111041

Price: $65


Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review compiles examples of novel synthetic compounds, which could be used as templates for developing novel drugs for the treatment of Cryptococcus infections.

Keywords: Antifungal, azole, cryptococcosis, Cryptococcus, heterocycles, natural product derivatives, peptide, phospholipidic compounds.

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