Title:Contributions on Kinetic Resolution by Lipases on the Development of Organic Synthesis in Brazil
Volume: 12
Issue: 6
Author(s): Leandro H. Andrade, Bruno A. Sousa, Irlon M. Ferreira and André L. M. Porto
Affiliation:
Keywords:
Biocatalysis, Lipases, Candida antarctica, Immobilization, Kinetic Resolution.
Abstract: In recent decades the need for new chiral compounds with high enantiomeric excesses
has been rapidly emerging. Among the various methods used to achieve chiral compounds, one
can highlight the enzymatic kinetic resolution of racemic esters, alcohols and amines and as the
most versatile enzymatic methodology used in organic routes. Enzymes are used in biocatalytic
routes to obtain enriched and enantiomerically pure compounds. The most remarkable biocatalysts
for these processes are lipases, which have the capability of being used in organic media.
Thus, the main purpose of this article was to present a review about studies conducted in Brazil
involving the kinetic resolution of racemic compounds using lipases, also including unusual substrates containing heteroatoms, such as
boron, silicon, selenium, tellurium and sulfur.
