Title:Investigative Approaches for Oral Delivery of Anticancer Drugs: A Patent Review
Volume: 10
Issue: 1
Author(s): Mohammad Tariq, Anu T. Singh, Zeenat Iqbal, Farhan J. Ahmad and Sushama Talegaonkar
Affiliation:
Keywords:
Anticancer agent, biconjugates, functional excipients, oral delivery, microparticulate system, nanoparticulate system,
patent survey, P-gp modulators, prodrugs.
Abstract: Typically, chemotherapy has been dominated by intravenous administration. Though, inclination
towards oral ingestion of chemotherapeutics is increasing since it offers ample of fascinating
opportunities including better quality of life, treatment advantages and low healthcare cost. However,
low or moderate bioavailability along with significant inter-patient variability and narrow therapeutic
window challenges their oral administration. Thus, optimization of oral route with maximized efficacy
and miniminal adverse events is a challenging area. To surmount the challenges, a number of strategies like
P-glycoprotein (P-gp) modulation, colloidal carrier etc. have been under investigation and scientists are exploring the utility
of solid dispersions, prodrugs, biconjugates, complexes, microparticulate, and nanoparticulate systems (liposome,
SLN, dendrimers, SEDDS, nanoparticles). Among these, nanoparticulate systems have shown promising results due to
their targeting potential and ability to alter absorption pathways. Functional excipients with P-gp modulating activity are
also being explored for more effective oral delivery of chemotherapeutics. This article explores the encouraging reports,
recent patents and inventions on the feasibility and applicability of oral administration of chemotherapeutics.
