Title:Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
Volume: 18
Issue: 2
Author(s): Laura Xicota, Jose Rodriguez-Morato, Mara Dierssen and Rafael de la Torre
Affiliation:
Keywords:
Alzheimer disease, (-)-epigallocatechin-3-gallate, green tea, neurodegenerative diseases, neuroprotection, oxidative
stress.
Abstract: Medical advances in the last decades have increased the average life expectancy, but also the
incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer’s disease (AD) is
one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora
of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development
and progression. So far, there are no pharmacological treatments available and the current
medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention
due to their interesting biological activities, and more specifically their antioxidant properties. (-)-
Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its
potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding
the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only
limited to its antioxidant activity, which may explain its beneficial health effects.
