Title:Experimental Brain Ischemic Preconditioning: A Concept to Putative Targets
Volume: 15
Issue: 4
Author(s): Ashish Sharma and Rohit Goyal
Affiliation:
Keywords:
Brain ischemic preconditioning, neurodegeneration, glycogen synthase kinase 3 beta, heat shock proteins, crosstolerance,
cytokines.
Abstract: Neurodegeneration is the progressive loss of central neurons which may instigate many disabling psychological
and neurological disorders like Alzheimer’s disease, schizophrenia, parkinson’s disease, prion’s disease, and Huntington’s
disease. It has become imperative to address the need to discover novel molecular targets and therapeutic strategies to
combat neurodegeneration. It is more essential to do so, because most of the accessible treatment focuses on correcting the
symptoms of such diseases rather than its underlying pathophysiology. In the present article, we sought to discuss
plausible connections between brain ischemic preconditioning and protective measures against chemical neurotoxicity.
Brain ischemic preconditioning is reported to be effective against stroke like conditions and is studied chiefly to identify
culpable molecular targets. Similarly chemical stressors are reported to be effective in preconditioning neuronal cells
against chemical neurotoxicity. Keeping the concept of cross-tolerance in mind this article encompasses the putative
targets of both chemical preconditioning and ischemic preconditioning in search for a suitable connection based on the
published literature. The distinctive groups of targets are individually discussed and principal targets such as oncogene
Akt, glycogen synthase kinase 3-beta and heat shock proteins are emphasised. Identification of these targets may help to
develop sophisticated newer therapeutic strategies to cure neurodegenerative disorders.
