Title:Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat
Volume: 15
Issue: 1
Author(s): Artemio Rosiles, Carmen Rubio, Cristina Trejo, Jessica Gutierrez, Leonardo Hernández and Carlos Paz
Affiliation:
Keywords:
Epilepsy, Cerebellum, Bergmann glia, Sox-1, β-catenin, Apoptosis.
Abstract: Epilepsy is one of the most common neurological disorders in humans, and the role of
cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex
regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus
nuclei, which form the main cerebellar output to other structures in the central nervous system
involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further
inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is
increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the
cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
