Abstract
An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a new template that has been used for the generation of a small library of molecules as potential cytotoxic agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed [3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.
Letters in Drug Design & Discovery
Title:Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents
Volume: 13 Issue: 3
Author(s): Koduru Sri Shanthi Praveena, Edupuganti Veera Venkat Shivaji Ramarao, Yedla Poornachandra, Chityal Ganesh Kumar, Nallapati Suresh Babu, Nandula Yadagiri Sreenivasa Murthy and Sarbani Pal
Affiliation:
Keywords: Quinoline, 1, 2, 3-triazole, oxime, cancer, PDE4.
Abstract: An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a new template that has been used for the generation of a small library of molecules as potential cytotoxic agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed [3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.
Export Options
About this article
Cite this article as:
Shanthi Praveena Sri Koduru, Venkat Shivaji Ramarao Veera Edupuganti, Poornachandra Yedla, Kumar Ganesh Chityal, Babu Suresh Nallapati, Sreenivasa Murthy Yadagiri Nandula and Pal Sarbani, Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents, Letters in Drug Design & Discovery 2016; 13 (3) . https://dx.doi.org/10.2174/1570180812999150819095308
DOI https://dx.doi.org/10.2174/1570180812999150819095308 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
DNA Methylation Leaves Its Mark in Head and Neck Squamous Cell Carcinomas (HNSCC)
Current Genomics Bioinformatics Approach to BDNF and BDNF-Related Disorders
Current Neuropharmacology The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Determination of 7,12-Dimethylbenz[a]Anthracene in Orally Treated Rats by High-Performance Liquid Chromatography and Transfer Stripping Voltammetry
Combinatorial Chemistry & High Throughput Screening Role of Imaging in Testicular Cancer
Current Medical Imaging Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer
Current Cancer Therapy Reviews Chemoinformatic Analysis of Biologically Active Macrocycles
Current Topics in Medicinal Chemistry Advances in Oncolytic Virus Therapy for Glioma
Recent Patents on CNS Drug Discovery (Discontinued) Therapeutic Potentials of Scavenger Receptor CD36 Mediated Innate Immune Responses Against Infectious and Non-Infectious Diseases
Current Drug Discovery Technologies The Current Status of Novel PET Radio-Pharmaceuticals in Radiotherapy Treatment Planning of Glioma
Current Pharmaceutical Biotechnology STAT 3 as a Target for Cancer Drug Discovery
Current Medicinal Chemistry Mammary Development and Breast Cancer: The Role of Stem Cells
Current Molecular Medicine Carcinogenesis and Diabetic Wound Healing: Evidences of Parallelism
Current Diabetes Reviews Subject Index To Volume 13
Current Medicinal Chemistry The Emerging Role of Vascular Endothelial Growth Factor (VEGF) in Vascular Homeostasis: Lessons from Recent Trials with Anti-VEGF Drugs
Current Vascular Pharmacology Hecogenin Acetate Inhibits Reactive Oxygen Species Production and Induces Cell Cycle Arrest and Senescence in the A549 Human Lung Cancer Cell Line
Anti-Cancer Agents in Medicinal Chemistry The Role of Mass Spectrometry in the “Omics” Era
Current Organic Chemistry Investigation of <i>ACE rs4646994, MTHFR rs1801133</i> and <i>VDR rs2228570</i> Genotypes in Jordanian Patients with Fibromyalgia Syndrome
Endocrine, Metabolic & Immune Disorders - Drug Targets Novel PARP Inhibitor DDPF-20 Induces DNA Damage and Inhibits Angiogenesis through the PI3K/Akt/VEGF Pathway
Anti-Cancer Agents in Medicinal Chemistry Mechanisms of Tumor Cell Necrosis
Current Pharmaceutical Design