Abstract
Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.
Keywords: autoimmunity, dendritic cells, endothelium, endothelial cell, migration, inflammation
Current Pharmaceutical Design
Title: Dendritic Cell Endothelium Interaction in Autoimmunity
Volume: 10 Issue: 2
Author(s): C. L. Schlichting, W. D. Schareck and M. Weis
Affiliation:
Keywords: autoimmunity, dendritic cells, endothelium, endothelial cell, migration, inflammation
Abstract: Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.
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Cite this article as:
Schlichting L. C., Schareck D. W. and Weis M., Dendritic Cell Endothelium Interaction in Autoimmunity, Current Pharmaceutical Design 2004; 10 (2) . https://dx.doi.org/10.2174/1381612043453397
DOI https://dx.doi.org/10.2174/1381612043453397 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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