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摘要
“inflammaging”是一种伴随内皮细胞功能显著下降和显著移向系统促炎症情形的衰老。这两种现象都加速和恶化了大多数通常与年龄相关疾病(ARDs)的病人病情,比如说癌症。长期细胞压力激活了促炎症组织,导致与衰老有关分泌表型(SASP)的发生和衰老通过分泌传播到周围细胞,这一发现证明了细胞衰老可能在两个过程中都起作用。在此我们1)描述细胞衰老在内皮细胞功能减退的作用。2)强调内皮细胞与衰老有关的分泌表型对inflammaging的促进作用。3)证明选择性的去除衰老的内皮细胞可能不仅可以阻碍这些有害的过程,还能减少ARDs发生的风险和他们的复杂性。虽然衰老内皮细胞体内检测和靶向还在进行研究,但是基于抗氧化和抗炎化合物的治疗战略将会包括普遍的抗衰老影响和有益于内皮细胞。微小RNA(miRNAs)是一种单链的非编码的RNA,在所有的活细胞中表达,与转录时的表观遗传调制有关,可能构成一个创新的有价值的工具来检测和瞄准衰老内皮细胞,发明治疗方法来减慢由衰老内皮细胞所诱发的促炎症程序。
关键词: 癌症,细胞衰老,内皮细胞,内皮细胞功能减退,炎症衰老,微小RNA,miR-126-3p,NFkB,衰老,超声波分解化合物,T2DM.
Current Drug Targets
Title:Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools
Volume: 17 Issue: 4
Author(s): Francesco Prattichizzo, Massimiliano Bonafe, Artan Ceka, Angelica Giuliani, Maria Rita Rippo and Massimo Re, Roberto Antonicelli, Antonio Domenico Procopio and Fabiola Olivieri
Affiliation:
关键词: 癌症,细胞衰老,内皮细胞,内皮细胞功能减退,炎症衰老,微小RNA,miR-126-3p,NFkB,衰老,超声波分解化合物,T2DM.
摘要: Aging is accompanied by a progressive decline of endothelial function and a progressive drift toward a systemic pro-inflammatory status that has been designated “inflammaging”. Both phenomena are accelerated and exacerbated in patients with the most common age-related diseases (ARDs), including cancer. The finding that chronic cell stress activates a pro-inflammatory program leading to acquisition of the senescence-associated secretory phenotype (SASP) and to the propagation of senescence to surrounding cells through the secretome, suggests that cell senescence may have a role in both processes. Here we: i) describe the role of cell senescence in endothelial dysfunction, ii) emphasize the contribution of the endothelial cell SASP to inflammaging, and iii) suggest that selective removal of senescent endothelial cells may not only hinder such harmful processes, but also reduce the risk of developing ARDs and their complications. Although in vivo detection and targeting of senescent endothelial cells are still being investigated, it is likely that therapeutic strategies based on antioxidant and anti-inflammatory compounds would involve generalized anti-aging effects also benefiting endothelial cells. MicroRNA (miRNAs) - single-stranded, non-coding RNAs expressed by all living cells and involved in the epigenetic modulation of all transcriptional programs - may constitute an innovative, valuable tool to detect and target senescent endothelial cells and to devise treatments that can slow down the pro-inflammatory program activated in senescent endothelial cells.
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Francesco Prattichizzo, Massimiliano Bonafe, Artan Ceka, Angelica Giuliani, Maria Rita Rippo and Massimo Re, Roberto Antonicelli, Antonio Domenico Procopio and Fabiola Olivieri , Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools, Current Drug Targets 2016; 17 (4) . https://dx.doi.org/10.2174/1389450116666150804105659
DOI https://dx.doi.org/10.2174/1389450116666150804105659 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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