Generic placeholder image

Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Current Management of Neonatal Soft-tissue Sarcomas and Benign Tumors with Local Aggressiveness

Author(s): Israel Fernandez-Pineda, Michael D. Neel and Bhaskar N. Rao

Volume 11, Issue 3, 2015

Page: [216 - 225] Pages: 10

DOI: 10.2174/1573396311666150714110840

Price: $65


Neonatal soft-tissue tumors are rare and comprise a heterogeneous group of neoplasms with substantial histological diversity. Treatment options include careful observation, primary surgical resection or medical therapy. Although histologically benign, some neoplasms do exhibit an aggressive local behavior. The most common soft-tissue sarcomas in this age group include rhabdomyosarcoma, fibrosarcoma, malignant rhabdoid tumor and hemangiopericytoma. Prenatal diagnosis on routine ultrasound or in the context of a known predisposition syndrome is increasingly becoming more common. Management of neonatal tumors requires a multidisciplinary team that includes obstetricians, neonatologists, pediatric oncologists, pediatric surgical specialists and psychological support for the family members. Treatment is particularly challenging due to the difficulty in appropriate dosing of chemotherapeutic agents or the limitations of the use of radiation therapy. Although surgical treatment is predominant in this age group, close observation may be appropriate, since spontaneous regression has been reported for certain histological subtypes.

Keywords: Fibrosarcoma, hemangiopericytoma, infantile myofibromatosis, malignant rhabdoid tumor, neonate, rhabdomyosarcoma, soft-tissue neoplasms.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy