Title:Recent Advances in the Development of Small-Molecular Inhibitors Target HIV Integrase-LEDGF/p75 Interaction
Volume: 15
Issue: 14
Author(s): Yu Zhao and Zaigang Luo
Affiliation:
Keywords:
HIV-1; integrase; LEDGF/p75; integrase-LEDGF/p75 interaction inhibitors .
Abstract: Lens epithelium-derived growth factor (LEDGF/p75) plays an essential role in the HIV-1
replication. It acts by tethering integrase (IN) into the host cellular chromatin. Due to its significance
of the IN-LEDGF/p75 interaction affords a novel therapeutic approach for the design of new classes of
antiretroviral agents. To date, many small molecules have been found to be the inhibitors of INLEDGF/
p75 interaction. This review summarizes recent advances in the development of potential
structure-based IN-LEDGF/p75 interaction inhibitors. The work will be helpful to shed light on the
antiretroviral drug development pipeline in the next future.