Title:Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity
Volume: 10
Issue: 3
Author(s): Rita Morigi, Alessandra Locatelli, Alberto Leoni and Mirella Rambaldi
Affiliation:
Keywords:
Antitumor, inhibitors, kinases, matrix metalloproteinases, patents, thiazole.
Abstract: Cancer is a disease of remarkable importance in the world today and is projected to become
the primary cause of death within the coming years, therefore the design and development of new antitumor
agents is one of the most pressing research areas in medicinal chemistry. Considering the importance
of thiazole ring as scaffold present in a wide range of therapeutic agents, the medicinal chemists
have been encouraged to synthesize a large number of novel antitumors bearing this heterocycle,
which furnish extensive synthetic possibilities due to the presence of several reaction sites. The present
review describes the patents from 2008 to present concerning new thiazole compounds useful for the
development of new drug molecules. It has been divided according to the molecular target and describes
the pathways involved in the biological activities and the structure of the most potent compounds,
together with the screening results.
