Title:Immunological Mechanisms of Neuropsychiatric Lupus
Volume: 11
Issue: 2
Author(s): Kyle C. Sinclair, Jonathan J. Miner and Alfred H.J. Kim
Affiliation:
Keywords:
Autoantibodies, blood-brain barrier, cytokines, neuropsychiatric lupus, systemic lupus erythematosus.
Abstract: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a clinical syndrome
characterized by various neurologic phenotypes in patients with systemic lupus erythematosus (SLE).
Mechanisms of NPSLE pathogenesis are not well understood although aberrant activation of both
innate and adaptive immune pathways is thought to play a role. Animal models suggest a variety of
factors that may instigate these neuropsychiatric events, including production of pathogenic
autoantibodies, release of proinflammatory cytokines, disruption of the blood-brain barrier, and
dysregulation of innate immune responses.
