Abstract
Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Letters in Organic Chemistry
Title:Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives
Volume: 12 Issue: 8
Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko and Makoto Hashimoto
Affiliation:
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Abstract: Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
Export Options
About this article
Cite this article as:
Yoshida Takuma, Wang Lei, Nakagawa Shiori, Tachrim Puteri Zetryana, Sakihama Yasuko, Hashidoko Yasuyuki and Hashimoto Makoto, Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives, Letters in Organic Chemistry 2015; 12 (8) . https://dx.doi.org/10.2174/1570178612666150629181357
DOI https://dx.doi.org/10.2174/1570178612666150629181357 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bronchoscopy in Children for Research with Questionable Indications: An Overview of Russian Patents and Publications
Recent Patents on Drug Delivery & Formulation Efficacy of Bronchial Artery Embolization for Clinically Suspected Bronchial Dieulafoy’s Disease
Current Medical Imaging CRISPeering: Bioengineering the Host Cells through CRISPRCas9 Genome Editing System as the Next-generation of Cell Factories
Recent Patents on Biotechnology Natural DNA Intercalators as Promising Therapeutics for Cancer and Infectious Diseases
Current Cancer Drug Targets Transmucosal Delivery of Linagliptin for the Treatment of Type- 2 Diabetes Mellitus by Ultra-Thin Nanofibers
Current Drug Delivery Nanoparticle-Based Inhalation Therapy for Pulmonary Diseases
Current Drug Metabolism Multi-component Reactions for the Synthesis of Biologically Relevant Molecules Under Environmentally Benign Conditions
Current Organic Chemistry The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds
Mini-Reviews in Medicinal Chemistry Comparative Proteome Profiles of Methicillin-Resistant <i>Staphylococcus aureus</i> in Response to Vanillic Acid and 2-Hydroxycinnamic Acid
Current Proteomics New Approved Medications for Idiopathic Pulmonary Fibrosis
Current Drug Therapy Sepsis and Solid Organ Transplantation
Current Drug Targets A Comparison of Non-Human Primate Cytochrome P450 2D Members and the Implication in Drug Discovery
Current Drug Metabolism Prevalence of Toxoplasma Encephalitis in AIDS Patients Treated with Didanosine Hospitalised in a French Infectious Service
Current HIV Research Thermal Stability of Thermoanaerobacter tengcongensis Ribosome Recycling Factor
Protein & Peptide Letters Pleural Involvement Due to Metastatic Melanoma: A Rare Complication and Literature Review
Current Respiratory Medicine Reviews Role of Genetic Interactions in Lung Diseases Detection Using Computational Approaches: A Review
Current Chinese Computer Science Antitubercular Natural Terpenoids: Recent Developments and Syntheses
Current Organic Synthesis Clinical Trials in Pakistan: Opportunities and Challenges
Applied Clinical Research, Clinical Trials and Regulatory Affairs Impact of Structural Domains of the Heparin Binding Hemagglutinin of Mycobacterium tuberculosis on Function
Protein & Peptide Letters A Brief Survey on Computational Approaches to Reveal Drug and Disease Associations
Current Drug Discovery Technologies