Title:Self-Emulsifying Systems for Oral Bioavailability Enhancement
Volume: 5
Issue: 2
Author(s): Afzal Hussain, Abdus Samad, Sandeep Kumar Singh and Sarwar Beg
Affiliation:
Keywords:
Bioavailability, hydrophobic drugs, self-emulsifying drug delivery systems.
Abstract: Hydrophobic drug entities are the major challenges for pharmaceutical scientists to deliver through oral
route of administration due to limited drug solubility and bioavailability particularly emerged from combinatorial
chemistry and computer aided drug design. Presently, self-emulsifying systems have been employed as the most
common approach for delivery of numerous poor aqueous drugs. This unique strategy exploits many lipids,
surfactants, co-surfactants and permeation enhancers to form an ideal isotropic mixture in water or gastric fluid by
gentle agitation. The chapter attempts to explore components of SEDDS in designing of drug delivery system to
accommodate significant amount of poorly soluble drugs, limitations of the system and their rectification, types of
SEDDS, evaluation of SEDDS and a short review of research in last decade involved to improve oral
bioavailability of drugs. The aim of this chapter is a throughout understanding of lipid based dosage form designing
and application in self-emulsifying drug delivery system from enhanced oral bioavailability point of view for drugs
possessing water solubility problem. Moreover, the present article would also provide a brief account of the patent
instances filed/approved in this domain for providing an updated account of the concept.