Title:Lipid-Based Systems for Delivery of Biological Macromolecules
Volume: 5
Issue: 2
Author(s): Afzal Hussain, Abdus Samad, Mohd Usman Mohd Siddique and Gajanand Sharma
Affiliation:
Keywords:
Absorption, biomacromolecules, lipid-based systems, novel carriers, permeation, solubility.
Abstract: Lipid-based drug delivery systems (LBDDS) are one of the most promising delivery systems for several
drugs with poor solubility and bioavailability after administration through oral route and other routes of
administration. A variety of drug candidates seek lipid based delivery owing to increased solubility and other
benefits as discussed drug-wise in this chapter elsewhere. It is noteworthy that lipid based drug delivery is
considered as innovative and acceptable strategy as compared to polymeric nanoparticles in terms of highest drug
loading, easy to scale-up on commercial scale in industries, being biocompatible and free from organic solvent in
the finished product. Recently, several biological macromolecules are delivered successfully in lipid based
formulations to protect them from intestinal enzymatic degradation, to improve solubility, to enhance
bioavailability and to commercialize easily. In this chapter, we focused delivery of several therapeutic biological
macromolecules which are facing problems in the formulation designing with enhanced efficacy and in vivo
performance. These systems consist of diverse group of formulations, each consisting of varying functional and
structural properties that are amenable to modifications achieved by varying the composition of lipid excipients and
other additives. These systems are basically solid lipid particulate dosage forms, nanoemulsion, nanostructured lipid
carrier, and vesicular systems. Thus, this chapter conclusively gives the advances in LBDDS for diverse biological
macromolecules. Moreover, the present article would also provide a brief account of the patent instances
filed/approved in this domain for providing an updated account of the concept.
