Title:Emerging Cytokines in Allergic Airway Inflammation: A Genetic Update
Volume: 12
Issue: 1
Author(s): Karim Daliri, Erfan Aref-Eshghi, Shahrouz Taranejoo, Shirin Modarresi, Atefeh Ghorbani, Ali Nariman, Mohsen Savaie, Seyed M.M. Falasiri, Fatemeh Akhondi-Kharangh and Hassan Askari
Affiliation:
Keywords:
Airway hyper responsiveness, asthma, cytokine, gene.
Abstract: Purpose: We aim to discuss the current status of knowledge on the role of recently identified cytokines in
airway hyper responsiveness as well as the genetic predisposition conferred by their coding genes to asthma.
Methods: We focused on three cytokines and their coding genes,IL-9, IL-17, and IL-22, and conducted a narrative review
of all the relevant publications known to the authors.
Results: A great body of evidence regarding the involvement of these three cytokines in asthma was discussed and
interpreted. These range from studies on the murine models of asthma to clinical and human genetic approaches. Despite
the large amounts of information existing on the genetics of IL-9 and IL-17, there is a lacking trend towards the IL-22
genetic studies in asthma.
Conclusion: The emergence of new classes of T-helper effector cells and their cytokines has led to a change in our
understanding of asthma pathogenesis. This has created both new opportunities and challenges for researchers involved in
this field, and is likely to result in improvements and progress in identifying and developing novel therapeutic measures
and innovative treatments for asthma.
