细胞衰老和相关致病过程中的内源性逆转录因子：与年龄相关疾病中有希望的药物靶点。

Title:Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases

Volume: 17 Issue: 4

Author(s): Maurizio Cardelli1,, Robertina Giacconi, Marco Malavolta and Mauro Provinciali

Affiliation:

关键词: Alu，癌症，与年龄相关疾病，细胞衰老，药物，炎症，LINE-1，逆转录转座子。

摘要: Endogenous retroelements (ERs) represent nearly half of the human genome. Considered up to recent years as “functionless” DNA sequences, they are now known to be involved in important cellular functions such as stress response and generation of non coding regulatory RNAs. Moreover, an increasing amount of data supports the idea of ERs as key players in cellular senescence and in different senescence-related pathogenic cellular processes, including those leading to inflammation, cancer and major age-related multifactorial diseases. The involvement of ERs in these biological mechanisms can suggest new therapeutic strategies in neoplasms, inflammatory/autoimmune diseases and in different age-related pathologies, such as macular degeneration, diabetes, cardiovascular diseases and major age-related neurodegenerative disorders. The therapeutic approaches which can be suggested range from a set of well-known, common drugs that have been shown to modulate ERs activity, to immune therapy against ER-derived tumor antigens, to more challenging strategies such as those based on anti-ERs RNA interference.

Cite this article as:

Maurizio Cardelli1,, Robertina Giacconi, Marco Malavolta and Mauro Provinciali , Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases, Current Drug Targets 2016; 17 (4) . https://dx.doi.org/10.2174/1389450116666150518095829