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摘要
胃癌和胃食管癌是世界第二死亡率高的癌症。诊断在不到50%案例中处于一个先进的阶段提供了一个尝试治疗。尽管系统性毒性化疗方案得到了改善,转移性胃癌和胃食管癌患者的预后仍不乐观。近期生物途径方面已经被允许进行潜在靶点的鉴定。HER2受体细胞外域参与细胞增殖以及抗凋亡过程发生在胃癌和胃食管癌细胞中。 Trastuzumab, 是靶向HER2的一种单克隆抗体,除了化疗,它可使对HER2阳性的胃癌和胃食管癌晚期患者获得超过一年的生存时间。近期,ramucirumab,一种靶向VEGFR-2受体的人造单克隆抗体对胃癌和胃食管癌晚期患者有效地表达出二线治疗作用。这些鼓舞人心的结果证明了靶向治疗的意义。本文综述了那些对晚期胃癌和胃食管癌患者治疗表现出潜在的临床有效性的靶向治疗。
关键词: 胃癌;胃癌;靶向治疗;抗血管内皮生长因子;抗表皮生长因子受体;曲妥单抗
Current Drug Targets
Title:Gastric Carcinoma at the Era of Targeted Therapies
Volume: 17 Issue: 15
Author(s): Johann Dreanic, Marion Dhooge, Elena Sion, Catherine Brezault, Stanislas Chaussade, Romain Coriat
Affiliation:
关键词: 胃癌;胃癌;靶向治疗;抗血管内皮生长因子;抗表皮生长因子受体;曲妥单抗
摘要: Gastric and gastro-esophageal cancers (GC/GEJ) appear as the second cancer-related death worldwide. Diagnosis is made at an advanced stage offering a curative attempt in less than 50% of cases. Despite the improvements of the systemic cytotoxic chemotherapy regimens, the prognosis of patients with metastatic GC/GEJ cancer remains poor. Recent insights in biochemical pathways have permitted to identify potential targets. The extracellular domain of HER2 receptors is implicated in cells’ proliferation and in the anti-apoptotic process occurring in GC/GEJ cancers. Trastuzumab, a monoclonal antibody targeting HER2, in addition to chemotherapy permitted to obtain more than one year of survival in HER2-positive advanced GC/GEJ cancers. Recently, ramucirumab, a humanized monoclonal antibody targeting VEGFR-2 receptor demonstrated its efficacy as a second line treatment for patients with advanced GC/GEJ cancer. These encouraging results have justified evaluating targeted therapies in GC/GEJ cancers. In this review, we summarize targeted therapies that might present clinical efficacy in the treatment of advanced GC/GEJ cancers.
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Cite this article as:
Johann Dreanic, Marion Dhooge, Elena Sion, Catherine Brezault, Stanislas Chaussade, Romain Coriat , Gastric Carcinoma at the Era of Targeted Therapies, Current Drug Targets 2016; 17 (15) . https://dx.doi.org/10.2174/1389450116666150506111327
DOI https://dx.doi.org/10.2174/1389450116666150506111327 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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