Title:Application of Resveratrol in Diabetes: Rationale, Strategies and Challenges
Volume: 15
Issue: 4
Author(s): P.K. Bagul and S.K. Banerjee
Affiliation:
关键词:
临床研究，胰岛素抗药性，分子机制，白藜芦醇，糖尿病，抗衰老酶
摘要: The increasing prevalence, involvement of several signaling pathways, variable
pathogenesis, progressive natural history and complications of type 2 diabetes emphasize an
urgent need for a molecule with multiple actions. Resveratrol (3,5,4'-trihydroxy-trans-stilbene)
is a polyphenolic antioxidant present in red wine gaining a worldwide interest because of its
multi-target effect against diabetes and other life-threatening diseases. Improving insulin
sensitivity, enhancing GLUT4 translocation, reducing oxidative stress, regulating
carbohydrate metabolizing enzymes, activating SIRT1 and AMPK, and decreasing
adipogenic genes are some promising mechanisms established until now for resveratrol. Apart from these,
resveratrol attenuates the end organ damage and reduced diabetic complications. Resveratrol exerts its
beneficial antidiabetic action as evidenced from the in vitro, preclinical and clinical studies. Considering all the
benefits of resveratrol in diabetes, resveratrol based different nutraceutical products have been developed
commercially to use in humans. However, this compound is still under investigation because of some
limitations. Resveratrol can be taken in to account in the treatment of diabetes after overcoming all hurdles and
difficulties. This article examines the basic scientific evidences, animal experiments, and human/clinical data
supporting the antidiabetic action of resveratrol and describes the strategies and challenges to recommend
resveratrol from preclinical to clinical use.
