Title:Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification
Volume: 16
Issue: 8
Author(s): Zoltan V. Varga, Zoltan Giricz, Peter Bencsik, Rosalinda Madonna, Mariann Gyongyosi, Rainer Schulz, Manuel Mayr, Thomas Thum, Laszlo G. Puskas and Peter Ferdinandy
Affiliation:
Keywords:
Microarray, microRNA, miRNA, mRNA, postconditioning, preconditioning, proteomics, risk factors, sequencing,
system biology, transcriptomics.
Abstract: Ischemic heart disease including myocardial infarction develops on the basis of several risk-factors and comorbidities
such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the leading cause
of mortality worldwide, therefore, identification of novel drug targets for cardioprotection is of great importance. Ischemic
preconditioning, postconditioning, and remote conditioning trigger endogenous cardioprotective mechanisms that render
the heart more resistant to lethal ischemic-reperfusion injury. However, major cardiovascular co-morbidities such as hyperlipidemia,
diabetes, and their co-medications interfere with these cardioprotective mechanisms thereby limiting the efficacy
of cardioprotective ischemic conditioning maneuvers. Ischemia reperfusion injury and cardioprotection by conditioning
have been shown to affect global myocardial gene expression profile at the transcript level. Further understanding
and the comprehensive analysis of the cardioprotective gene expression fingerprint in normal, protected, and in comorbid
conditions may lead to identification of novel molecular targets for cardioprotection.
