摘要
在过去几年,充分的数据表明低度恶性炎症在动脉粥样硬化和心血管疾病的病理生理学中的关键作用。在动脉粥样硬化的慢性阶段作为介质或在急性阶段作为触发器的炎症激活增多了心血管疾病已被明确研究。就高血压而言,炎症过程通过双向关系涉及其病理生理学,因此高血压可能会加重炎症,反之亦然。炎症生物标记物,如高灵敏度C-反应蛋白,表明高血压发病率和高血压患者的临床结果的预测值。本文中,有关高血压和低度恶性炎症之间的联系的数据将被报道,这种联系潜在的病理生理学途径和临床意义将会被讨论。
关键词: 抗炎药物,高血压,内皮功能紊乱,低度恶性炎症,亚临床器官损伤。
Current Medicinal Chemistry
Title:Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction
Volume: 22 Issue: 23
Author(s): Panagiota Pietri, Charalambos Vlachopoulos and Dimitris Tousoulis
Affiliation:
关键词: 抗炎药物,高血压,内皮功能紊乱,低度恶性炎症,亚临床器官损伤。
摘要: Over the last years, ample data have demonstrated the pivotal role of low-grade inflammation in the pathophysiology of atherosclerosis and cardiovascular disease. It is well established that inflammatory activation, serving either as a substrate, in the chronic phase of atherosclerotic disease, or as a trigger, in the acute phase, increases cardiovascular events. Considering hypertension, the inflammatory process is implicated in its pathophysiology through a bidirectional relationship since arterial hypertension may enhance inflammation and vice versa. Inflammatory biomarkers such as highsensitivity C-reactive protein, have shown predictive value for both the incidence of hypertension and the clinical outcomes in hypertensive patients. In the present review, data on the association between arterial hypertension and low-grade inflammation will be reported and potential pathophysiological pathways and clinical implications underlying this association will be discussed.
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Panagiota Pietri, Charalambos Vlachopoulos and Dimitris Tousoulis , Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction, Current Medicinal Chemistry 2015; 22 (23) . https://dx.doi.org/10.2174/0929867322666150420104727
DOI https://dx.doi.org/10.2174/0929867322666150420104727 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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