Title:Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Volume: 15
Issue: 15
Author(s): Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang
Affiliation:
Keywords:
Vinca alkaloids, Drug delivery systems, Combination therapy, Vincristine, Vinblastine, Vinorelbine, Vindesine,
Vinflunine, Vinpocetine.
Abstract: Developing new methods for chemotherapy drug delivery has become a topic of great concern.
Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however,
their side effects are particularly problematic for many medical doctors. To reduce the toxicity
and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies
such as using liposome-entrapped drugs, chemical- or peptide-modified drugs, polymeric packaging
drugs, and chemotherapy drug combinations. This review mainly focuses on the development of a
vinca alkaloid drug delivery system and the combination therapy. Five vinca alkaloids (eg, vincristine,
vinblastine, vinorelbine, vindesine, and vinflunine) are reviewed.
