增加相互联系： 皮质类固醇结合球蛋白在心脏类固醇促进作用所起的作用

Title:Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation

Volume: 16 Issue: 11

Author(s): Hans Hendrik Schafer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna Kaiser

Affiliation:

关键词: 皮质类固醇结合球蛋白，药物，糖皮质激素，心脏，人类，盐皮质激素。

摘要: Corticosteroid (glucocorticoids [GCs] and mineralcorticoids [MCs]) interact directly with cells of the cardiovascular system. Their signaling affects genomic and non-genomic receptors and comprises a multitude of alternative and interfering levels of interaction, which influence the physiological response. This review describes genomic and non-genomic pathways of steroid facilitation and portrays the current body of knowledge regarding corticosteroid-binding globulin (CBG). The latter is a carrier protein facilitating corticosteroid availability in the circulation and has recently been discovered intrinsically in cardiomyocytes. Thought experiments highlight potential areas of clinical research and hypotheses are presented for steroid- carrier interaction. Furthermore, this review comprises a conclusive overview of disease conditions and substances that influence CBG levels and summarizes the potential of CBG as a potential future biomarker.

Cite this article as:

Hans Hendrik Schafer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna Kaiser , Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/1389450116666150408103806