Title:Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease
Volume: 12
Issue: 4
Author(s): Ahmed E. Abdel Moneim
Affiliation:
Keywords:
Alzheimer’s disease, antioxidants, oxidative stress.
Abstract: Alzheimer's disease (AD) is the most common form of dementia characterized by progressive
loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary
tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating
evidence has shown that oxidative stress–induced damage may play an important role in the initiation
and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between
the production and quenching of free radicals from oxygen species. These reactive oxygen species
augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and
vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties
of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review,
the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize.
