摘要
免疫性血小板减少性紫癜(ITP)是最常见的自身免疫性疾病,是由抗体介导的血小板和巨核细胞-血小板生成受损产生的。ITP是一种排除性诊断。最近ITP的病理生理机制和治疗方法已开始出现。虽然类固醇和静脉注射免疫球蛋白(IVIg)仍然是主要的治疗策略,一组患者最终产生了耐药性,尤其是近十年已经有一些生物治疗方案,如利妥昔单抗。在这篇综述中,我们总结了ITP患者的治疗方案,主要集中在时间和生物制剂的潜在影响。
关键词: 自身免疫性疾病,生物治疗,免疫性血小板减少性紫癜,利妥昔单抗。
Current Medicinal Chemistry
Title:Immune Thrombocytopenic Purpura: New Biological Therapy of an Old Disease
Volume: 22 Issue: 16
Author(s): Melda Comert Ozkan, Fahri Sahin and Guray Saydam
Affiliation:
关键词: 自身免疫性疾病,生物治疗,免疫性血小板减少性紫癜,利妥昔单抗。
摘要: Immune Thrombocytopenic Purpura (ITP) is the most common autoimmune disorder that is caused by antibody- mediated destruction of thrombocytes and impaired megakaryocyte platelet production. ITP remains a diagnosis of exclusion. Recent pathophysiologic mechanisms and therapeutical approaches of ITP have emerged. Although steroids and intravenous immunglobulins (IVIg) have still been the main therapeutic strategies, a group of patients develop resistance to those eventually and there have been some biological treatment options such as rituximab especially in the last decade. In this review article, we have summarized the therapeutic options for patients with ITP and mainly focused on the timing and potential effects of biological agents.
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Cite this article as:
Melda Comert Ozkan, Fahri Sahin and Guray Saydam , Immune Thrombocytopenic Purpura: New Biological Therapy of an Old Disease, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150319102830
DOI https://dx.doi.org/10.2174/0929867322666150319102830 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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