Hypoxia PET Tracers in EBRT Dose Planning in Head and Neck Cancer

Title:Hypoxia PET Tracers in EBRT Dose Planning in Head and Neck Cancer

Volume: 8 Issue: 1

Author(s): Marina Hodolic, Jure Fettich and Kalevi Kairemo

Affiliation:

Keywords: Head and neck cancers, hypoxia, PET/CT tracers, radiotherapy planning.

Abstract: Over the years, external beam radiotherapy (EBRT) has been used in the treatment management of many malignancies, including head and neck squamous cell carcinomas (HNSCC). Hypoxia is a common feature in HNSCC. Hypoxic segments in HNSCC have proven to be more resistant to radiotherapy. The ability to identify hypoxia using SPECT and PET tracers has been investigated since the late 1970s. Nitroimidazole-based compounds labelled with positron emitters have been developed to more specifically image hypoxia. This article reviews the current data from research publications on¹⁸F–FMISO, ¹⁸F-FAZA, ¹⁸F-EF5 and ⁶⁴Cu-ATSM.

Cite this article as:

Hodolic Marina, Fettich Jure and Kairemo Kalevi, Hypoxia PET Tracers in EBRT Dose Planning in Head and Neck Cancer, Current Radiopharmaceuticals 2015; 8 (1) . https://dx.doi.org/10.2174/1874471008666150316222400