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Abstract
Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulose on earth. Unlike other natural polymers, the cationic charge possessed by chitosan is accountable for imparting interesting physical and chemical properties. Chitosan has been widely exploited for its mucoadhesive character, permeation enhancing properties and controlled release of drugs. Moreover it’s non-toxic, biocompatible and biodegradable properties make it a good candidate for novel drug delivery system. This review provides an insight on various chitosan based formulations for drug delivery. Some of the current applications of chitosan in areas like ophthalmic, nasal, buccal, sublingual, gastro-retentive, pulmonary, transdermal, colon-specific and vaginal drug delivery have been discussed. In addition, active targeting of drugs to tumor cells using chitosan has been described. Lastly a brief section covering the safety aspects of chitosan has also been reviewed.
Keywords: Biocompatible, biodegradable, chitosan, controlled release, drug delivery, mucoadhesive character.
Current Drug Delivery
Title:Chitosan: A Propitious Biopolymer for Drug Delivery
Volume: 12 Issue: 4
Author(s): Dibyangana S. Duttagupta, Varsha M. Jadhav and Vilasrao J. Kadam
Affiliation:
Keywords: Biocompatible, biodegradable, chitosan, controlled release, drug delivery, mucoadhesive character.
Abstract: Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulose on earth. Unlike other natural polymers, the cationic charge possessed by chitosan is accountable for imparting interesting physical and chemical properties. Chitosan has been widely exploited for its mucoadhesive character, permeation enhancing properties and controlled release of drugs. Moreover it’s non-toxic, biocompatible and biodegradable properties make it a good candidate for novel drug delivery system. This review provides an insight on various chitosan based formulations for drug delivery. Some of the current applications of chitosan in areas like ophthalmic, nasal, buccal, sublingual, gastro-retentive, pulmonary, transdermal, colon-specific and vaginal drug delivery have been discussed. In addition, active targeting of drugs to tumor cells using chitosan has been described. Lastly a brief section covering the safety aspects of chitosan has also been reviewed.
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Cite this article as:
Duttagupta S. Dibyangana, Jadhav M. Varsha and Kadam J. Vilasrao, Chitosan: A Propitious Biopolymer for Drug Delivery, Current Drug Delivery 2015; 12 (4) . https://dx.doi.org/10.2174/1567201812666150310151657
DOI https://dx.doi.org/10.2174/1567201812666150310151657 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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