Title:Ion Channels as Medicinal Targets of Biological Toxins: The Impact of Automated Patch-Clamp Electrophysiology
Volume: 15
Issue: 7
Author(s): Arturo Picones
Affiliation:
Keywords:
Automated patch-clamp electrophysiology, Ion channels, Toxins.
Abstract: Patch-Clamp electrophysiology, the “gold standard” for the functional study of ion channels
has become automated. This innovative technology, already over a decade old, has revolutionized
the strategies for the search of medicinal compounds which now can be screened at unprecedented
speed, approaching the high throughput standards required by primary screening campaigns emblematic
of the pharmaceutical and biotechnology industries. Consequently, an acceleration of the discovery
and development of new drugs targeting ion channels is expected. These pore forming membrane
proteins had been relegated as crucial therapeutic drug targets due to the difficulty of their experimental
analysis. This new technological approach has begun to impact the finding of new toxins which are conspicuously
relevant as medicinal agents given their extraordinary potency and specificity when acting upon ion channels. The introduction
of automated patch-clamp instrumentation to academic labs and institutions pursuing the finding of new pharmacological
agents, peptide toxins in particular, will certainly enrich these scientific and technological fields by contributing
with their always prolific generosity of originality and innovation.
