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摘要
在上世纪70到80年代,双胍类的降糖药苯乙双胍(PF)和丁福明(BF)已被证明可以对动物癌变模型产生抑制作用和 增加癌症患者的生存期5到10年。自2005年以来,在二甲双胍(MF)第一次被发表以后,另一个双胍,为避免二型糖尿病患者(T2D)恶性肿瘤的发展和抑制小鼠体内的肿瘤发生,开始将研究领域主要集中在乳腺癌,胰腺癌,前列腺癌,子宫内膜癌和其他一些癌症方面。结直肠癌(CRC)是消化系统肿瘤中最常见的一个。在此综述中提出了可用数据 来表明双胍类药物的降糖能力—防止大肠癌的发展和体外生长以及体外的实验模型和临床观测。
关键词: 结直肠癌,二甲双胍,预防,治疗。
Current Drug Targets
Title:Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data
Volume: 17 Issue: 4
Author(s): Vladimir N. Anisimov
Affiliation:
关键词: 结直肠癌,二甲双胍,预防,治疗。
摘要: In the 70-80th of last century, it has been shown that the antidiabetic biguanide drugs phenformin (PF) and buformin (BF) can exert an inhibitory action on carcinogenesis in animal models and increase from 5 to 10-years survival of cancer patients. Since 2005, after first evidence publication of the capacity of metformin (MF), another biguanide, to prevent development of malignant tumors in individuals with type 2 diabetes (T2D) and suppress tumorigenesis in mice, the burst of studies started in this field focused on breast, pancreas, prostatic, endometrial and some other cancers. Colorectal cancer (CRC) is the most prevalent among digestive system cancers. In this mini-review are presented the available data on the capacity of antidiabetic biguanide drugs to prevent colorectal carcinogenesis and growth in vitro and in vivo in experimental models and clinical observations.
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Cite this article as:
Vladimir N. Anisimov , Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data, Current Drug Targets 2016; 17 (4) . https://dx.doi.org/10.2174/1389450116666150309113305
DOI https://dx.doi.org/10.2174/1389450116666150309113305 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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