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摘要
急性髓系白血病(AML)是第一个恶性肿瘤的免疫治疗,以异基因造血干细胞移植(allo-HSCT)的形式,被整合到标准的护理。异基因造血干细胞移植的不过是一个具有显著的发病率和死亡率的不完美的治疗,而只提供不完全预防白血病复发。这些限制促使寻找白血病相关抗原,可作为免疫治疗更具针对性和有效性的目标。而历史上这样的研究都集中在唯一的急性髓系白血病或显着较高的水平比在正常组织中表达的蛋白靶点,本文将回顾最近的研究发现了一种新的潜在的靶抗原的白血病免疫治疗的选择,如非蛋白的目标包括脂类和碳水化合物,新抗原基因的体细胞突变或改变剪接和蛋白质翻译后修饰的创建目标,结合创新的方式表达的蛋白靶点的靶细胞表面抗原肽-MHC复合物。这些新的抗原表现出有前途的候选人的进一步发展为急性髓系白血病的治疗目标。
关键词: 急性髓系白血病,抗原,免疫治疗
Current Drug Targets
Title:Novel Antigen Targets for Immunotherapy of Acute Myeloid Leukemia
Volume: 18 Issue: 3
Author(s): Meghali Goswami, Christopher S. Hourigan.
Affiliation:
关键词: 急性髓系白血病,抗原,免疫治疗
摘要: Acute myeloid leukemia (AML) was the first malignancy for which immunotherapy, in the form of allogeneic hematopoietic stem cell transplantation (allo-HSCT), was integrated into the standard of care. Allo-HSCT however is an imperfect therapy associated with significant morbidity and mortality while offering only incomplete prevention of AML clinical relapse. These limitations have motivated the search for AML-related antigens that might be used as more specific and effective targets of immunotherapy. While historically such investigations have focused on protein targets expressed uniquely in AML or at significantly higher levels than in normal tissues, this article will review recent discoveries which have identified a novel selection of potential antigen targets for AML immunotherapy, such as non-protein targets including lipids and carbohydrates, neo-antigens created from genetic somatic mutations or altered splicing and post-translational modification of protein targets, together with innovative ways to target overexpressed protein targets presented by cell surface peptide-MHC complexes. These novel antigens represent promising candidates for further development as targets of AML immunotherapy.
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Cite this article as:
Meghali Goswami, Christopher S. Hourigan. , Novel Antigen Targets for Immunotherapy of Acute Myeloid Leukemia, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450116666150223120005
DOI https://dx.doi.org/10.2174/1389450116666150223120005 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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