Title:Anti-Inflammatory and Antioxidant Properties of Piper Species: A Perspective from Screening to Molecular Mechanisms
Volume: 15
Issue: 9
Author(s): Sarvesh Kumar, Shashwat Malhotra, Ashok K. Prasad, Erik V. Van der Eycken, Marc E. Bracke, William G. Stetler-Stevenson, Virinder S. Parmar and Balaram Ghosh
Affiliation:
Keywords:
Anti-inflammatory, Antioxidant, Cell adhesion molecules (CAMs), Endothelial cells, Piper longum, Piper galeatum.
Abstract: Identifying novel therapeutic agents from natural sources and their possible intervention
studies has been one of the major areas in biomedical research in recent years. Piper species are highly important - commercially,
economically and medicinally. Our groups have been working for more than two decades on the identification
and characterization of novel therapeutic lead molecules from Piper species. We have extensively studied the biological
activities of various extracts of Piper longum and Piper galeatum, and identified and characterized novel molecules from
these species. Using synthetic chemistry, various functional groups of the lead molecules were modified and structure activity
relationship (SAR) studies identified synthetic molecules with better efficacy and lower IC50 values. Moreover, the
mechanisms of actions of some of these molecules were studied at the molecular level. The objective of this review is to
summarize experimental data published from our laboratories and others on antioxidant and anti-inflammatory potentials
of Piper species and their chemical constituents.
