Title:Bothrops pauloensis Snake Venom Toxins: The Search for New Therapeutic Models
Volume: 15
Issue: 7
Author(s): Veridiana M. Rodrigues, Daiana S. Lopes, Leticia E. Castanheira, Sarah N. C. Gimenes, Dayane L. Naves de Souza, David C. Ache, Isabela P. Borges, Kelly A.G. Yoneyama and Renata S. Rodrigues
Affiliation:
Keywords:
Antithrombotic, Antitumor, Bothrops pauloensis, C- type lectins, L-amino acid oxidases, Metalloproteinases, Phospholipases
A2, Serine proteinase.
Abstract: Snake venoms constitute a mixture of bioactive components that are involved not only in
envenomation pathophysiology but also in the development of new drugs to treat many diseases. Different
enzymatic and non-enzymatic proteins, such as phospholipases A2, hyaluronidases, L-amino
acid oxidases, metalloproteinases, serine proteinases, lectins and disintegrins have been isolated and
their functional and structural properties described in the literature. Many of these studies have also
explored their medicinal potential focusing mainly on anticancer, antithrombotic and microbicide
therapies. Bothrops pauloensis is a species found in Brazil, whose venom has been the focus of our
studies in order to explore the biochemical and functional characteristics of their components. In this review, we have presented
the main results of years of research on different toxins from B. pauloensis emphasizing their therapeutic potential.
Studies concerning snake venom toxins to search for new therapeutic models open perspectives for new drug discovery.