Title:MicroRNA and Bone Tumor: To Up Date
Volume: 9
Issue: 3
Author(s): Huichao Wang, Ruiqiang Zhang, Yudong Jia, Xiaodong Zhang, Yingjie Zhu, Ying Zhang, Xiantao Chen, Xiaoqiang Zhang, Litao Cai, Hanzheng Zhao, Wuyin Li and Youwen Liu
Affiliation:
Keywords:
Bone tumor, Ewing sarcoma, microRNA, osteosarcoma.
Abstract: In the last several years, bone tumor related microRNA research showed an explosive
growth. MicroRNA was found to have a high or low expression level in bone tumor tissue and some
microRNAs proved to be the biomarker for poor prognosis. The majority of research was focused on
osteosarcoma and Ewing sarcoma. Many tumor associated molecules, including oncogenes and tumor
suppressor genes, were found to be the direct targets for microRNA, and enhanced microRNA may
play the regulatory role in tumor development. In the bone tumor cell lines, overexpression of
microRNA could promote or inhibit the tumor growth, migration, invasion, and metastasis, especially
for osteosarcoma and Ewing sarcoma. Many key molecules proved important for tumor genesis were found directly
binding to the related microRNA, and whose expression level was down regulated. This may provide a novel therapeutic
target for bone tumor. Large scale clinical samples detection and high through-put microarray assay have demonstrated
microRNA might be applied to predict and diagnose the bone tumor. MicroRNA in serum was also proved significant as a
biomarker for bone tumor.
