Title:Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection
Volume: 15
Issue: 5
Author(s): Upinder Kaur, Priyanjalee Banerjee, Aritri Bir, Maitrayee Sinha, Atanu Biswas and Sasanka Chakrabarti
Affiliation:
Keywords:
Alzheimer’s disease, Amyloid beta, Cytokines, NF-κB, Oxidative stress, Redox signaling.
Abstract: Oxidative stress and inflammatory response are important elements of Alzheimer's disease
(AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators
have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling
cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream
components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in
the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and
experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs
for AD targeting NF-κBsignaling cascade has been discussed in the end.
