Title:Small Heat Shock Proteins and the Endoplasmic Reticulum: Potential Attractive Therapeutic Targets?
Volume: 15
Issue: 1
Author(s): L. Zeng, J. Tan, T. Lu, Q. Lei, C. Chen and Z. Hu
Affiliation:
关键词:
细胞凋亡，癌症，细胞保护，内质网（ER）应激，小热休克蛋白（sHsps）
摘要: The endoplasmic reticulum(ER) is crucial for protein and lipid synthesis,
folding and cellular homeostasis. Function impairment of ER would induce ER stress,
which might play an important role in many different pathological states. Small heat
shock proteins (sHsps) are known to be widely expressed throughout many tissues.
SHsps are found to regulate many different pathological and pathophysiological
processes and they are supposed to be potential therapeutic targets. Recent studies
indicate that multiple sHsps localize to the mammalian and plant ER and sHsps confer
protection against ER stress in multiple cellular processes. The mechanisms responsible
for the cytoprotective effects of sHsps are related to maintaining ER homeostasis.
Improved understanding of sHsps-related cytoprotective action on ER and successful
strategies which could specifically target components of ER stress signalling responses
amelioration of their toxic effects by sHsps is of great importance in the development of therapeutic approach
for the disorders induced by dysfunction of ER.
