Title:Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases
Volume: 16
Issue: 3
Author(s): Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska, Marta Sobczak, Jakub Fichna and Martin Kreis
Affiliation:
Keywords:
Anti-platelet agents, inflammatory bowel diseases, platelets, thrombosis.
Abstract: Platelets play a crucial role in immune responses. Impaired platelet activation may cause
persistent mucosal inflammation through P-selectin, CD40-CD40L and other systems influencing
granulocytes, macrophages or endothelial cells. Pharmacological regulation of platelet activation may
reduce thromboembolism and limit the interaction of platelets with endothelial and inflammatory cells,
in turn weakening the inflammatory responses. In this review we focus on pathophysiological activities of platelets in inflammatory
bowel diseases and discuss the studies on currently available anti-platelet therapies in the treatment of gastrointestinal
inflammation. Finally, we provide a prospective view to new anti-platelet agents currently under development.
