Title:OPA1 in Cardiovascular Health and Disease
Volume: 16
Issue: 8
Author(s): Niall Burke, Andrew R. Hall and Derek J. Hausenloy
Affiliation:
关键词:
心血管疾病,裂变,融合,线粒体形态学,视神经萎缩蛋白1
摘要: Mitochondria are known to play crucial roles in normal cellular physiology and in more recent
years they have been implicated in a wide range of pathologies. Central to both these roles is their
ability to alter their shape interchangeably between two different morphologies: an elongated interconnected
network and a fragmented discrete phenotype - processes which are under the regulation of the
mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial
fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we
explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.