Title:Oxidative Stress and Neurodegenerative Diseases: Looking for a Therapeutic Solution Inspired on Benzopyran Chemistry
Volume: 15
Issue: 5
Author(s): Alexandra Gaspar, Nuno Milhazes, Lourdes Santana, Eugenio Uriarte, Fernanda Borges and Maria Joao Matos
Affiliation:
Keywords:
Neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease, Oxidative stress, Chromones, Coumarins.
Abstract: Reactive species are continuously produced in vivo by all body tissues. However, when an imbalance
between the reactive species production and the endogenous pool of antioxidants occurs, the resulting
oxidative stress can somehow intensify the pathophysiological mechanisms of several diseases, such as
neurodegenerative diseases. Although the aetiology of Parkinson’s and Alzheimer’s diseases is not yet
completely understood, it is accepted by the scientific community that the oxidative stress can act as a trigger or can be
involved in the course of both diseases. Therefore, the development of an antioxidant-based therapy could be a helpful
approach to ameliorate the deleterious effects of oxidative stress in neurodegenerative diseases. Coumarins and chromones
are natural or synthetic chemical entities described as privileged structures with diverse biological activities that
have been used to design new drugs with potential anti-Alzheimer and anti-Parkinson profiles. Since some of these compounds
also displayed potent antioxidant activity, the rationale approach to developing new drugs based on the benzopyran
scaffold, as therapeutic alternatives for neurodegenerative diseases, is a valid and compelling topic. This review
provides a medicinal chemistry overview on the discovery and development of benzopyran-based compounds endowed
with antioxidant, neuroprotective and anti-Alzheimer or anti-Parkinson activities.
