Title:Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches
Volume: 15
Issue: 2
Author(s): Xiaoyu Wang, Zongguang Tai, Wei Zhang and Shen Gao
Affiliation:
Keywords:
Gene therapy, hepatocellular carcinoma, non-viral vector, physical methods, viral vectors.
Abstract: Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates,
especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe
gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems,
including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial
development. Among them, various non-viral vectors have been studied widely and in detail because
they are relatively safe and have a high capacity. In this review, we focus on current and emerging
HCC delivery techniques and address the challenges involved in the use and improvement of non-viral
vectors.