Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives

Title:Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives

Volume: 2 Issue: 2

Author(s): Ambareen Shaikh and Jyotsna S. Meshram

Affiliation:

Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.

Abstract: In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, ¹H NMR, ¹³C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.

Cite this article as:

Shaikh Ambareen and S. Meshram Jyotsna, Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives, Current Microwave Chemistry 2015; 2 (2) . https://dx.doi.org/10.2174/2213335602666141217222008