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Current Microwave Chemistry

Editor-in-Chief

ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Facile Microwave-Assisted Synthesis and Pharmacological Appraisal of Bioactive Dihydropyrimidinone Derivatives

Author(s): Ambareen Shaikh and Jyotsna S. Meshram

Volume 2, Issue 2, 2015

Page: [166 - 172] Pages: 7

DOI: 10.2174/2213335602666141217222008

Price: $65

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Abstract

In this paper, we report a rapid and facile synthesis of a series of some dihydropyrimidinone derivatives 4(a-e) and 5(a-e) under microwave radiation. All the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analyses. The compounds were screened for in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against gram positive and gram negative strains of bacteria. This pharmacological assessment data revealed that compounds 4c and 5c showed good anti-inflammatory activity. Besides, compounds 4a, 4c, 5b, 5c and 5e gave excellent results for the anti-bacterial activity evaluation against the selected strains of bacteria.

Keywords: Anti-bacterial, anti-inflammatory, chloroquinoline, dihydropyrimidinone, 1, 3, 4-oxadiazole, pyrazolone.

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