橄榄中齐墩果酸及相关三萜有利于血管机能的分子机制和治疗前景

Title:Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives

Volume: 22 Issue: 11

Author(s): Rosalia Rodriguez-Rodriguez

Affiliation:

关键词: 心血管疾病，齐墩果酸，橄榄中的五环三萜，血管功能

摘要: Oleanolic acid and related triterpenoids from olives modulate different signaling pathways, showing a wide range of pharmacological activities against inflammation, cancer or cardiovascular diseases. In particular, emerging evidences reveal the potential of oleanolic acid to restore vascular disorders associated to cardiovascular risk factors, i.e. hypertension, obesity and diabetes, and atherosclerosis. During the previous years, in vitro and in vivo studies with these triterpenoids have positioned them as being mainly responsible for cardiovascular risk protection traditionally associated to olive oil. This review updates recent investigations in olive oil triterpenoids function related to cardiovascular diseases, as well as the underlying mechanisms and structural implications. Important aspects of olive oil triterpenoids such as bioavailability and clinical perspectives on cardiovascular disorder are also extensively analyzed. All these investigations evidence the potential of triterpenoids from olive oil as a promising therapeutic strategy against vascular function, thus efficiently preventing the progression of cardiovascular diseases.

Cite this article as:

Rosalia Rodriguez-Rodriguez , Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives, Current Medicinal Chemistry 2015; 22 (11) . https://dx.doi.org/10.2174/0929867322666141212122921