Abstract
A new one-pot three-component and highly efficient approach for the synthesis of quinoxaline derivatives was investigated. This was achieved via two methods from the reaction of α-hydroxy ketones or 1,2-dicarbonyl compounds with o-phenylenediamine in the presence of catalytic amount of many metal salt catalysts especially Zn(OAc)2 and mixture of Mn(OAc)2 and Zn(OAc)2.
Keywords: Quinoxaline, 1, 2-dicarbonyl compounds, α-hydroxyketone, metal salts, in-Situ oxidation, one-pot procedure.
Letters in Organic Chemistry
Title:A Comprehensive Comparison Metal Salts Effect on Time and Yield of Quinoxalines Synthesis
Volume: 12 Issue: 1
Author(s): Ardeshir Khazaei, Heidar Ali Alavi Nik and Payam Rahmani
Affiliation:
Keywords: Quinoxaline, 1, 2-dicarbonyl compounds, α-hydroxyketone, metal salts, in-Situ oxidation, one-pot procedure.
Abstract: A new one-pot three-component and highly efficient approach for the synthesis of quinoxaline derivatives was investigated. This was achieved via two methods from the reaction of α-hydroxy ketones or 1,2-dicarbonyl compounds with o-phenylenediamine in the presence of catalytic amount of many metal salt catalysts especially Zn(OAc)2 and mixture of Mn(OAc)2 and Zn(OAc)2.
Export Options
About this article
Cite this article as:
Khazaei Ardeshir, Alavi Nik Ali Heidar and Rahmani Payam, A Comprehensive Comparison Metal Salts Effect on Time and Yield of Quinoxalines Synthesis, Letters in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/1570178612666141211224503
DOI https://dx.doi.org/10.2174/1570178612666141211224503 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace
Current Drug Targets Non-Invasive Tests in Animal Models and Humans: A New Paradigm for Assessing Efficacy of Biologics Including Prebiotics and Probiotics
Current Pharmaceutical Design Oncolytic Virotherapy and Gene Therapy Strategies for Hepatobiliary Cancers
Current Cancer Drug Targets Novel Tyrosine Kinase Inhibitors in the Treatment of Cancer
Current Drug Targets uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy
Current Drug Targets EBV-Related Malignancies, Outcomes and Novel Prevention Strategies
Infectious Disorders - Drug Targets Galectin-9 in Cancer Therapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery New Concepts for Glaucoma Implants - Controlled Aqueous Humor Drainage, Encapsulation Prevention and Local Drug Delivery
Current Pharmaceutical Biotechnology In Silico Modeling of Crabtree Effect
Endocrine, Metabolic & Immune Disorders - Drug Targets Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review
Mini-Reviews in Medicinal Chemistry The Role of the ATP-Binding Cassette Transporter P-Glycoprotein in the Transport of β-Amyloid Across the Blood-Brain Barrier
Current Pharmaceutical Design Lactobacillus GG (LGG) Peptides Can Inhibit Antibiotic-Resistant Bacteria Growth
Anti-Infective Agents in Medicinal Chemistry lGnRH-III - a Promising Candidate for Anticancer Drug Development
Protein & Peptide Letters Polyisoprenylation Potentiates the Inhibition of Polyisoprenylated Methylated Protein Methyl Esterase and the Cell Degenerative Effects of Sulfonyl Fluorides
Current Cancer Drug Targets Episcopic 3D Imaging Methods: Tools for Researching Gene Function
Current Genomics A Computational Approach to Identify Novel Potential Precursor miRNAs and their Targets from Hepatocellular Carcinoma Cells
Current Bioinformatics Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates
Current Topics in Medicinal Chemistry Procyanidin B2 3,3″-di-O-gallate Inhibits Endothelial Cells Growth and Motility by Targeting VEGFR2 and Integrin Signaling Pathways
Current Cancer Drug Targets Uncertainty in the Translation of Preclinical Experiments to Clinical Trials. Why do Most Phase III Clinical Trials Fail?
Current Gene Therapy Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells
Anti-Cancer Agents in Medicinal Chemistry