Abstract
Vaccines are primarily employed for triggering the acquired immune response of the body to combat against diverse pathogenic organisms. Conventional approaches for vaccine delivery possess multiple challenges for effective delivery owing to lack of potential for targeting ability to a particular antigen and protection of antigens from physiological environments of body. In the past a few decades, nanocolloidal carriers have gained higher attention in vaccine delivery due to advantages of targeting ability, reduced immunogenicity and significant augmentation in immune response. Instances of colloidal carriers employed for vaccine delivery include liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles, reconstituted influenza viruses, immunostimulating complexes, antigen cochleates, etc. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies has yielded enhanced immune recognition potential to the vaccine antigens for eliciting immune response by promoting differentiation of the antigen specific memory T-cells. In a nutshell, the present review provides an updated and exhaustive account on the recent advancements in various colloidal delivery systems employed for vaccine delivery outlining their potential applications, mechanism of augmenting the immune response and instances of the products existing in market in an explicit manner.
Keywords: Nanocarriers, vaccines, liposomes, IRIVs, niosomes, immune response.
Current Drug Therapy
Title:Novel Nanocolloidal Carriers for Noninvasive Vaccine Delivery
Volume: 9 Issue: 3
Author(s): Sarwar Beg, Mahfoozur Rahman, Suryakanta Swain and Syed Sarim Imam
Affiliation:
Keywords: Nanocarriers, vaccines, liposomes, IRIVs, niosomes, immune response.
Abstract: Vaccines are primarily employed for triggering the acquired immune response of the body to combat against diverse pathogenic organisms. Conventional approaches for vaccine delivery possess multiple challenges for effective delivery owing to lack of potential for targeting ability to a particular antigen and protection of antigens from physiological environments of body. In the past a few decades, nanocolloidal carriers have gained higher attention in vaccine delivery due to advantages of targeting ability, reduced immunogenicity and significant augmentation in immune response. Instances of colloidal carriers employed for vaccine delivery include liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles, reconstituted influenza viruses, immunostimulating complexes, antigen cochleates, etc. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies has yielded enhanced immune recognition potential to the vaccine antigens for eliciting immune response by promoting differentiation of the antigen specific memory T-cells. In a nutshell, the present review provides an updated and exhaustive account on the recent advancements in various colloidal delivery systems employed for vaccine delivery outlining their potential applications, mechanism of augmenting the immune response and instances of the products existing in market in an explicit manner.
Export Options
About this article
Cite this article as:
Beg Sarwar, Rahman Mahfoozur, Swain Suryakanta and Imam Sarim Syed, Novel Nanocolloidal Carriers for Noninvasive Vaccine Delivery, Current Drug Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574885509666141202233804
DOI https://dx.doi.org/10.2174/1574885509666141202233804 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Surface Antigens/Receptors for Targeted Cancer Treatment: The GnRH Receptor / Binding Site for Targeted Adenocarcinoma Therapy
Current Cancer Drug Targets Biomarkers of Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD), A Review of Published Patents and Patent Applications
Recent Patents on Biomarkers DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease
Current Genomics Potential Anticancer Properties of Bisphosphonates: Insights From Preclinical Studies
Anti-Cancer Agents in Medicinal Chemistry Secretory Leukocyte Protease Inhibitor: More than Just A Protease Inhibitor
Current Immunology Reviews (Discontinued) Female Infertility and Assisted Reproduction: Impact of Oxidative Stress-- An Update
Current Women`s Health Reviews Releasing of Herpes Simplex Virus Carrying NGF in Subarachnoid Space Promotes the Functional Repair in Spinal Cord Injured Rats
Current Gene Therapy Fundamentals of Nanocarriers and Probiotics in the Treatment of Cervical Cancer
Current Nanomedicine Recent Approaches for Studying the Role of Glia
CNS & Neurological Disorders - Drug Targets Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers
Current Topics in Medicinal Chemistry Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note
Current Bioactive Compounds The Role of SAPK/JNK Pathway in the Synergistic Effects of Metformin and Dacarbazine on Apoptosis in Raji and Ramos Lymphoma Cells
Current Molecular Pharmacology In Situ Modulation of Oxidative Stress: A Novel and Efficient Strategy to Kill Cancer Cells
Current Medicinal Chemistry Nanoparticle-Delivered Quercetin for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Exploring Cytotoxic and Atioxidant Properties of <i>Heliotropium calcareum</i> in Polar and Non-Polar Extracts
Current Nutraceuticals Different 6-Aryl-Fulvenes Exert Anti-proliferative effects on Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Noscapine and its Analogs as Chemotherapeutic Agent: Current updates
Current Topics in Medicinal Chemistry NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization
Current Pharmaceutical Design Applications of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) in Pulmonary Disease
Current Respiratory Medicine Reviews Micronutrients at the Interface Between Inflammation and Infection Ascorbic Acid and Calciferol. Part 2: Calciferol and the Significance of Nutrient Supplements
Inflammation & Allergy - Drug Targets (Discontinued)