Title:Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents
Volume: 12
Issue: 1
Author(s): Mazaahir Kidwai, Roona Poddar, Arti Jain, Rakesh Kumar and Pratibha M. Luthra
Affiliation:
Keywords:
Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
Abstract: A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol
with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were
screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity
against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive
structure-activity relationships.