Abstract
The features of the chemistry of 4-thiazolidinone and isatin as privileged scaffolds were described in a number of reviews in which the main approaches to the synthesis of mentioned heterocycles and their pharmacological action were analyzed. However, the 4-thiazolidinone-indoline conjugates as well as isatin based heterocyclic hybrids as biologically active compounds is poorly discussed in the context of pharmacophore hybrid approach. Therefore, the purpose of this review is to summarize the data about the synthesis and biological activity of heterocyclic systems with thiazolidinone and 2-oxoindoline fragments in molecules and other heteryl-substituted indolines as promising objects of modern organic and medicinal chemistry.
Keywords: Biological activity, indolines, synthesis, 4-thiazolidinones.
Mini-Reviews in Organic Chemistry
Title:Synthesis, Biological Activity of Thiazolidinones Bearing Indoline Moiety and Isatin Based Hybrids
Volume: 12 Issue: 1
Author(s): Dmytro Havrylyuk, Borys Zimenkovsky and Roman Lesyk
Affiliation:
Keywords: Biological activity, indolines, synthesis, 4-thiazolidinones.
Abstract: The features of the chemistry of 4-thiazolidinone and isatin as privileged scaffolds were described in a number of reviews in which the main approaches to the synthesis of mentioned heterocycles and their pharmacological action were analyzed. However, the 4-thiazolidinone-indoline conjugates as well as isatin based heterocyclic hybrids as biologically active compounds is poorly discussed in the context of pharmacophore hybrid approach. Therefore, the purpose of this review is to summarize the data about the synthesis and biological activity of heterocyclic systems with thiazolidinone and 2-oxoindoline fragments in molecules and other heteryl-substituted indolines as promising objects of modern organic and medicinal chemistry.
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Havrylyuk Dmytro, Zimenkovsky Borys and Lesyk Roman, Synthesis, Biological Activity of Thiazolidinones Bearing Indoline Moiety and Isatin Based Hybrids, Mini-Reviews in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/1570193X11666141028231910
DOI https://dx.doi.org/10.2174/1570193X11666141028231910 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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