Title:Extending the Clinical Horizons of Mucosal Bacterial Vaccines: Current Evidence and Future Prospects
Volume: 15
Issue: 12
Author(s): Silvia Sanchez-Ramon, Rebeca Perez de Diego, Romina Dieli-Crimi and Jose-Luis Subiza
Affiliation:
Keywords:
Immunomodulation, mucosal immune system, mucosal bacterial vaccines, recurrent infections.
Abstract: Antibiotics remain the mainstay of treatment for infectious diseases, but the growing frequency of antibiotic resistance
represents a major concern for healthcare worldwide. The use of antibiotics in recurrent infections raises other issues,
such as their limitations for treating diverse microorganisms, deleterious effects on the microbiota of the patient and
potential adverse effects. In recent years, progress has been made towards the development of novel polybacterial vaccines
administered via the mucosal route. These drugs target both the innate and adaptive immune systems, at the actual
point of entry of most pathogens. In addition to boosting immune responses, mucosal bacterial vaccines have an intriguing
immunomodulatory activity that does not compromise their efficacy against infectious agents. We review here the current
clinical evidence concerning the efficacy and safety of these mucosal vaccines for the prevention and treatment of recurrent
infection. We also provide an overview completing the landscape of the potential clinical uses of these active biological
agents.
